Enrichment of a fraction toxic to guinea-pigs from Pachystigma pygmaeum (Schltr.) Robyns.

نویسندگان

  • J A Verschoor
  • H G Patterton
  • D J Potgieter
چکیده

Pachystigma pygmaeum is one of several species of rubiaceous plants which cause delayed heart failure among ruminants after their ingestion at relatively high doses. Using guinea-pigs for toxicity determinations, we were able to separate and enrich a toxic fraction from a fermentation extract of the plant material by countercurrent distribution. It contained virtually no potassium salts, passed through a 500 dalton selective membrane, exhibited lability under acid conditions and was toxic at 1 g/kg per os, with a delayed response of 3-4 days.

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عنوان ژورنال:
  • The Onderstepoort journal of veterinary research

دوره 52 2  شماره 

صفحات  -

تاریخ انتشار 1985